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循環腫瘤細胞（Circulating tumor cell，CTC）發現已久，作為腫瘤轉移和複發的關鍵因素，研究自發現以來從未止步。這些關鍵性的發現，讓我們能夠了解CTC，從而研發出相應的檢測技術。作為液態活檢（←戳鏈接看介紹）標誌物的重要一類，CTC檢測技術在腫瘤診療個體化的當下也愈發成熟。本期我們追根溯源，歡迎來到CTC的發現史！# 參考文獻 #[1] Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. [2] Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. [3] Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells. [4] Detection of circulating tumor cells in blood using an optimized density gradient centrifugation.[5] Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.[6] Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts.[7] A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis.[8] The distribution of secondary growths in cancer of the breast. [9] A flattened mouse embryo: Leveling the playing field.[10] A case of cancer in which cells similar to those in the tumors were seen in the blood after death.